Toxicol Appl Pharmacol. 2013 Mar 15;267(3):276-83. doi: 10.1016/j.taap.2013.01.005. Prolonged exposure to the vapour or slight skin exposure over a period of time affects the nervous system and the blood, causing tiredness, loss of appetite, headache, and dizziness. Pharmacol. Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Although microbial metabolism of aniline is well-studied, its toxic effects and physiological responses of microorganisms to aniline are largely unexplored. In silico analysis and molecular modeling of three highly up-regulated proteins revealed that these proteins were homologous to CpxARP proteins of ESR signalling pathway. Proteomic data reveal the up-regulation of envelope stress response proteins to aniline exposure. Human cancer data are insufficient to conclude that aniline is a cause of bladder tumors while animal studies indicate that aniline causes tumors of the spleen. The spleen toxicity of aniline is studied more and the different mechanisms are suggested. Aniline exposure is associated with toxicity to the spleen which is characterized by splenomegaly, hyperplasia, fibrosis, and a variety of sarcomas on chronic exposure in rats. Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats. In industry, aniline is an initiator or intermediary in the synthesis of a wide variety of products, most notably polyurethane foam, agricultural chemicals, analgesics, synthetic dyes, antioxidants, stabilizers for the ru…  |  Toxicol. Present address: Department of Plant Sciences, Avvaiyar Government College for Women, Karaikal, Puducherry U.T-609602, India. This review summarizes those events following aniline exposure that induce spleen toxicity and neurotoxicity. -. To understand the mechanism(s) of aniline-induced splenic toxicity, single and multiple (four and seven) doses of 1 mmol/kg of aniline hydrochloride(AH) were given in rats. The doses were based on earlier studies that had shown spleen toxicity and carcinogenicity in male rats at 100 mg/kg/day but not at 10 mg/12/kg/day. ROS/RNS also induce fibrogenic and pro-inflammatory mediators. Steiniger B., Barth P. Microanatomy and function of the spleen; Adv. We use cookies to help provide and enhance our service and tailor content and ads. Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid. Although microbial metabolism of aniline is well-studied, its toxic effects and physiological responses of microorganisms to aniline are largely unexplored. Aniline is a major environmental pollutant of serious concern due to its toxicity. Aniline | C6H5NH2 or C6H7N | CID 6115 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. This review aimed at clarifying if aniline itself or one of its … Ma H, Wang J, Abdel-Rahman SZ, Boor PJ, Khan MF. https://doi.org/10.1016/j.jhazmat.2019.121571. http://dx.doi.org/10.1016/j.taap.2005.08.006, NCI CPTC Antibody Characterization Program. 1999;151(iii-ix):1–101. Embryol. Animals were euthanized at 24 h following the last dose. Mechanism-based or time-dependent P 450 inhibitors pose an addnl. Epub 2013 Jan 23. Keywords: 2014;147(4):R105–R117. Aniline is synthesized by catalytic hydrogenation of nitrobenzene or by ammonolysis of phenol. To elucidate the mechanism(s) of splenic toxicity of aniline, studies were conducted with nitrosobenzene (NB), an N -oxidized metabolite of aniline. Aniline-induced methemoglobinemia, loss of circulating blood cells, blood … Rubrivivax benzoatilyticus JA2, an aniline non-degrading bacterium, tolerates high concentrations of aniline and produces extracellular polymeric substance (EPS). Furthermore, EPS formation to known ESR activators(Triton-X-100, EDTA) suggests that envelope stress possibly regulating the EPS production. Our study revealed the hitherto unknown toxic effects of aniline as an acute envelope stressor thus toxicity of aniline may be more profound to life-forms than previously thought. aniline dihydrofluoride. Aniline induces extracellular polymeric substance and aggregates formation in strain JA2. aniline hydrochloride-(14)C-labeled cpd. The damaged hemoglobin can not carry oxygen. Twelve substituted phenols and ten substituted anilines were chosen to investigate if the dose addition and independent action models can be used to evaluate the mixture toxicity of phenolic and aniline derivatives (PADs). 2 Mechanism of Action 2.1 Primary effects: erythrocytes The effects of aniline are manifest primarily in the erythrocytes in the form of the dose-related formation of methaemoglobin. Enhanced expression of cyclins and cyclin-dependent kinases in aniline-induced cell proliferation in rat spleen. It is proposed that compound-derived toxicity to erythrocytes results in scavenging of damaged red blood cells by the spleen, initiating a series of … The IARC lists it in Group 3 (not classifiable as to its carcinogenicity to humans) due to the limited and contradictory data available. Crit Rev Toxicol. 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